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And Other Appearance and Performance Enhancing Drugs (APEDs) Research Report What can be done to prevent steroid misuse. Increased androgen plasma concentrations suppress gonadotropin-releasing hormone (reducing endogenous testosterone), luteinizing hormone, and follicle-stimulating hormone by a negative-feedback mechanism. Raloxifene still acts as an antiestrogen in the brain, increasing the incidence of hot flashes (Davies. Most developed transdermal delivery, and will hopefully be launched as a transdermal delivery method.

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